Computational investigations on target-site searching and recognition mechanisms by thymine DNA glycosylase during DNA repair process

DNA glycosylase, as one member of DNA repair machineries, plays an essential role in correcting mismatched/damaged DNA nucleotides by cleaving the N-glycosidic bond between the sugar and target nucleobase through the base excision repair (BER) pathways.Efficient corrections of these DNA lesions are critical for maintaining genome integrity and prev

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Establishment of a novel indicator of pyroptosis regulated gene transcription level and its application in pan-cancer

Abstract Pyroptosis is a type of programmed Allergy Relief cell death and plays a dual role in distinct cancers.It is elusive to evaluate the activation level of pyroptosis and to appraise the involvement of pyroptosis in the occurrence and development of diverse tumors.Accordingly, we herein established an indicator to evaluate pyroptosis related

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Understanding Nursing Knowledge of Continence Care and Bladder Scanner Use in Long-Term Care: An Evaluation Study

Because urinary continence is an essential indicator for quality of life for older adults in long-term care, it is important to accurately assess and treat those at risk for incontinence.This evaluation study was to increase understanding of the issues related to the implementation of bladder scanners while exploring nursing staff knowledge about c

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RoIFusion: 3D Object Detection From LiDAR and Vision

When localizing and detecting 3D objects for autonomous driving scenes, obtaining information from multiple sensors (e.g., camera, LIDAR) is capable of mutually offering useful complementary information to enhance BURGUNDY PWD the robustness of 3D detectors.In this paper, a deep neural network architecture, named RoIFusion, is proposed to efficient

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